Clinical trials provide a pathway to determine the effectiveness of a treatment or therapy related to the diagnosis, prevention or management of a disease or condition. Before treatments can be used by the general public they must undergo a series of clinical trials, called phases, and be approved by relevant regulatory agencies (such as the FDA in the United States and the TGA in Australia). There are typically four phases of clinical trials starting with Phase 1 which focuses on the safety and appropriate dose of the treatment, Phase II will then determine the effectiveness and side effects of the treatment. Phase III sees the expansion of the trial to a larger participant cohort and will compare the new treatment to existing treatments. A successful Phase III trial can lead to drug approval. Phase IV will monitor the long- term effects of the approved treatment.

Those taking part in clinical trials are called trial participants and they are volunteers who may be healthy or have a specific illness or condition.

Amplia is currently involved in clinical trials to develop new treatments for people with pancreatic and ovarian cancer.